Alpha Centauri is the star system closest the Solar System consisting of three stars, Proxima Centauri, Alpha Centauri A and Alpha Centauri. It is 4.37 light years away from the Sun with Proxima Centauri being closest.
Alpha Centauri appears in almost all Civilization games. Building a spaceship to travel from Earth to a hatibable planet within the Alpha Centauri system before the other civilizations do so is a way of winning the game.
One game takes place there: Sid Meier's Alpha Centauri.