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The Strategic Defense Initiative gives your civilization some defense against ICBMs and nuclear missiles.
- Main article: SDI Defense (Civ1)
- Main article: SDI Defense (Civ2)
- Main article: SDI Defense (Civ3)
- Main article: SDI Defense (Civ4)
SDI Defense is not present in (or the article has not been created for) the following games :
|Civilization VI||SDI Defense (Civ6)|
|Civilization: Beyond Earth||SDI Defense (CivBE)|
|Civilization Revolution||SDI Defense (CivRev)|
|Civilization Revolution 2||SDI Defense (CivRev2)|
|Freeciv||SDI Defense (Freeciv)|
|Civilization: Call to Power||SDI Defense (CTP1)|
|Call to Power II||SDI Defense (CTP2)|
|C-evo||SDI Defense (C-evo)|
|FreeCol||SDI Defense (Freecol)|
|Sid Meier's Alpha Centauri||SDI Defense (SMAC)|